Acute Hepatitis
Hepatocyte injury : swelling (ballooning degeneration) Cholestasis : canalicular bile plugs HCV : mild focal fatty change of hepatocytes Hepatocyte necrosis : isolated cells or clusters Cytolysis (rupture) or apoptosis forming Councilman bodies If severe: bridging necrosis (portal-portal, central-central, portal-central) Lobular disarray : loss of normal architecture Regenerative changes : hepatocyte proliferation Sinusoidal cell reactive changes: Accumulation of phagocytosed cellular debris in Kupffer cells Influx of mononuclear cells into sinusoids Portal tracts: Inflammation: 1)predominantly mononuclear 2)Inflammatory spillover into adjacent parenchyma, with hepatocyte necrosis.